Syfovre (pegcetacoplan) is a brand-name drug prescribed for an advanced form of macular degeneration in adults. Syfovre comes as an eye injection that’s given by an eye doctor once every 25–60 days.

The Food and Drug Administration (FDA) has approved Syfovre to treat geographic atrophy due to dry age-related macular degeneration (AMD) in adults. (There are two types of AMD: wet and dry. Dry AMD is more common than wet AMD.)

Syfovre belongs to a drug class called complement inhibitors. Syfovre isn’t available in a generic version.

Keep reading for specific information about the dosage of Syfovre, including its strength and how the medication is given. For a comprehensive look at Syfovre, see this article.

Note: This article describes the typical dosage for Syfovre provided by the drug’s manufacturer. However, your doctor will prescribe the Syfovre dosage that’s right for you.

The information below describes Syfovre’s typical dosage and other details about the drug.

Syfovre form

Syfovre comes as a solution for injection into the eye. An eye doctor who specializes in the retina will give your injections at their office.

Syfovre strength

Syfovre comes in one strength: 15 milligrams per 0.1 milliliters of solution (150 mg/mL).

Typical dosage

The following information describes the Syfovre dosage that’s commonly prescribed or recommended. However, your doctor will determine the best dosage to fit your needs.

Dosage for geographic atrophy related to age-related macular degeneration

Doctors may prescribe Syfovre to treat geographic atrophy due to dry age-related macular degeneration.

If your doctor prescribes Syfovre, your dose will likely be 15 mg (0.1 mL of 150 mg/mL solution) by injection. You’ll receive an injection into each affected eye once every 25–60 days. This is the typically recommended dosage.

For more information about your specific dosage and injection frequency, talk with your doctor.

Long-term treatment

Syfovre is meant to be a long-term treatment. If you and your doctor determine that the drug is safe and effective for you, you’ll likely receive Syfovre injections long term.

Before you start Syfovre treatment, your doctor will discuss your treatment plan with you.

Syfovre is given as an intravitreal injection. Your eye doctor will inject the drug into the vitreous fluid (a thick, jelly-like liquid in the back of your eye).

Your doctor will use eye drops or gel to numb your eye area before your injection. They’ll also clean your eye and eyelid with a special solution to get rid of any bacteria that might be present. They may use a device called an eyelid speculum to keep your eye open during the injection. You may feel some pressure when your doctor injects Syfovre.

Depending on your dosing schedule, you’ll likely receive Syfovre injections every 25–60 days.

If you have questions about what to expect with Syfovre injections, talk with your doctor or pharmacist. There are also more details on the drug manufacturer’s website.

If you miss an appointment for your Syfovre injections, call your doctor’s office as soon as possible. They’ll reschedule your appointment and adjust your dosing schedule as needed.

If you need help remembering your appointments, try setting an alarm or downloading a reminder app on your phone.

Below are some frequently asked questions about Syfovre and dosage.

How long does it take for Syfovre to start working?

Syfovre starts to work after your first dose. But you likely won’t feel the drug working in your body. The drug is meant to slow vision loss that occurs with geographic atrophy. Your doctor can determine how well the drug is working by performing regular eye exams during treatment.

Talk with your doctor if you have questions about what to expect with Syfovre treatment.

Can I get my Syfovre injections more often than once every 25 days?

No, it’s not recommended to get Syfovre injections more often than once every 25–60 days. For details about Syfovre dosages, see the “Syfovre dosage” section above.

If you have questions or concerns about your Syfovre dosage, talk with your doctor. They’ll decide how often you should receive Syfovre injections.

The dosage in this article is the typical dosage provided by the drug’s manufacturer. If your doctor recommends Syfovre for you, they’ll prescribe the dosage that’s right for you.

If you have questions about the dosage of Syfovre that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Syfovre. These additional articles might be helpful:

  • More about Syfovre. For information about other aspects of Syfovre, refer to this article.
  • Cost. If you’d like to learn about Syfovre and cost, see this article.
  • Details about your condition. For details about your condition, see our eye health hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.